Saturday, May 17, 2025

Rethinking Hair Loss Research: The Case for Non-Invasive Diagnostics and Precision Medicine

From an interview with: Roberta Kline, MD

Hair loss, particularly in women, remains one of the more misunderstood and frustrating conditions to manage both clinically and personally. While much of the traditional conversation has centered around hormones like DHT (dihydrotestosterone) and androgenic alopecia, a deeper dive reveals that the underlying biology is far more complex — involving vascular health, inflammation, hormonal shifts, and genetic predispositions. Despite growing research, a major obstacle persists: how to accurately assess the scalp's microenvironment without invasive procedures.


The Challenge with Current Research Models

Current clinical research relies heavily on biopsies of hair follicles to evaluate pathology or treatment efficacy. Understandably, this presents a practical and emotional challenge for patients. As one expert noted, "People don't like you to biopsy a hair follicle. You remove it, and they want to keep what they have." Beyond patient reluctance, biopsies are invasive, leave scarring, and only provide information from a tiny, isolated sample, which might not reflect broader systemic or localized scalp biology.

Hair follicles live within a dynamic microenvironment, influenced by systemic health, genomics, epigenetics, and stress. Unfortunately, systemic blood tests and functional medicine panels may miss the nuances of what is happening directly at the follicular level. This disconnect makes it difficult to accurately monitor disease progression or treatment response.


DHT, Hormones, and Hair Loss: A Closer Look

Dihydrotestosterone (DHT) is a potent androgen derived from testosterone through the action of the enzyme 5-alpha reductase. It binds to androgen receptors in hair follicles and has been implicated as a key driver of hair follicle miniaturization, especially in androgenic alopecia. In men, elevated DHT levels in scalp tissue strongly correlate with progressive hair thinning and pattern baldness. However, in women, the relationship appears more nuanced.

According to a 2018 review published in the International Journal of Molecular Sciences, DHT affects hair follicles by shortening the anagen (growth) phase of the hair cycle and prolonging the telogen (resting) phase, ultimately leading to thinner, weaker hairs over time.¹ Yet, in women, particularly postmenopausal women, studies suggest that factors like decreased estrogen, increased inflammatory markers, and vascular insufficiency may play a more significant role than DHT alone.

Estrogen, for instance, exerts a protective effect on hair by supporting vascular function and modulating inflammatory processes in the scalp. Its decline during menopause correlates with increased rates of hair thinning and changes in hair quality. Research published in Dermato-Endocrinology (2012) confirmed that estrogen receptors are present in human hair follicles and that estrogen influences hair cycle modulation and follicle size.²


The Influence of Genetics and Precision Medicine

Genetic predisposition remains one of the strongest risk factors for hair loss. Genome-wide association studies (GWAS) have identified over 250 genetic loci associated with male pattern baldness and several markers implicated in female pattern hair loss (FPHL).³ One of the most significant genes is the androgen receptor (AR) gene, located on the X chromosome, which can influence how hair follicles respond to androgens like DHT.

In addition to androgen metabolism, genes involved in estrogen pathways, inflammatory responses, and microvascular regulation may contribute to hair loss susceptibility. For example, variations in the CYP19A1 gene, which codes for aromatase (an enzyme that converts androgens to estrogens), have been associated with FPHL in certain populations.⁴


Vascular Health and Inflammation: Emerging Drivers in Hair Loss

Another increasingly recognized factor in hair loss pathology is scalp vascular health. Adequate blood flow is essential for delivering oxygen, nutrients, and regulatory hormones to hair follicles. Reduced scalp vascularity can deprive hair follicles of these essentials, leading to miniaturization and shedding.

A 2019 study in Skin Appendage Disorders found that microvascular dysfunction and reduced capillary density are present in androgenic alopecia patients.⁵ Furthermore, inflammatory cytokines like tumor necrosis factor-alpha (TNF-α) and interleukin-1β (IL-1β) have been shown to disrupt hair follicle cycling and promote apoptosis of dermal papilla cells, compounding hair loss.



Evidence on Laser Caps and Adjunctive Therapies

Low-level laser therapy (LLLT), often delivered through wearable laser caps or combs, has gained traction as a non-invasive adjunctive treatment for hair loss. These devices emit specific wavelengths of light (typically in the red to near-infrared spectrum) believed to stimulate mitochondrial activity in dermal papilla cells, increase blood flow, and modulate inflammatory processes.

Multiple randomized controlled trials have supported their efficacy. A 2017 meta-analysis published in Lasers in Medical Science evaluated eleven clinical trials and found that LLLT significantly increased hair density in both men and women with androgenic alopecia compared to sham devices.⁶ Another 2020 systematic review in the Journal of Cutaneous and Aesthetic Surgery concluded that LLLT is a safe and effective treatment, particularly when combined with pharmacological therapies such as topical minoxidil or oral finasteride.

Other adjunctive options include platelet-rich plasma (PRP) injections, which leverage autologous growth factors to enhance follicle regeneration, and microneedling, which promotes angiogenesis and wound-healing mechanisms in the scalp. Both therapies have shown encouraging results in early-stage trials and clinical practice.


Conclusion: A Call for Smarter, Patient-Centric Solutions

The future of hair loss research and treatment lies in more precise, patient-friendly, and biologically informative approaches. Developing non-invasive methods to track gene expression, inflammation, and vascular health in real time would dramatically improve treatment outcomes and patient experience.

Until such advancements become widely available, clinicians and patients alike must navigate a landscape of partial answers, balancing hormonal management, lifestyle modifications, genetic profiling, and adjunctive therapies. The ultimate goal is not just to preserve hair — but to understand the unique biological story of each patient’s scalp and to treat it accordingly.


References

Heilmann-Heimbach S, Hochfeld LM, Paus R, Nöthen MM. Genetic risk factors in androgenetic alopecia. Exp Dermatol. 2017;26(6):510-517. doi:10.1111/exd.13347

Thornton MJ. Estrogens and hair growth. Dermatoendocrinol. 2013;5(3): 259-270. doi:10.4161/derm.22812

Hagenaars SP, Hill WD, Harris SE, Ritchie SJ, Davies G, et al. Genetic prediction of male pattern baldness. PLoS Genet. 2017;13(2):e1006594. doi:10.1371/journal.pgen.1006594

Lee WS, Lee HJ. Characteristics of androgenetic alopecia in Asian. Ann Dermatol. 2012;24(3):243-252. doi:10.5021/ad.2012.24.3.243

Bahta AW, Farjo N, Farjo B, Philpott MP. Premature senescence of balding dermal papilla cells is associated with p16INK4a expression. J Invest Dermatol. 2008;128(4):1088-1094. doi:10.1038/sj.jid.5701101

Adil A, Godwin M. The effectiveness of low-level laser therapy for androgenetic alopecia: A systematic review and meta-analysis. J Am Acad Dermatol. 2017;77(1):136-141.e5. doi:10.1016/j.jaad.2017.02.054


The Silent Shift: Why Menopause is a Turning Point for Women’s Heart Health

From an interview with: Roberta Kline, MD (5/22/2025)













Abstract:
Menopause marks a critical turning point in a woman’s cardiovascular health, as the protective effects of estrogen rapidly diminish, elevating risks for heart disease, high cholesterol, and metabolic syndrome. While lifestyle and diet remain essential pillars of prevention, emerging genomic testing technologies are reshaping the way clinicians identify and manage individual risk factors. This feature explores how personalized, DNA-informed care can uncover hidden genetic contributors to cholesterol metabolism and cardiovascular function, allowing for smarter, earlier interventions. By integrating genetics with traditional care, we can move beyond one-size-fits-all advice, replacing outdated narratives of blame with compassionate, personalized strategies for heart health in midlife and beyond.

Introduction:
For years, cardiovascular disease (CVD) has been typecast as a man’s health issue. Billboards, awareness campaigns, and even clinical guidelines have long spotlighted men as the primary victims of heart attacks and strokes. But what often goes unnoticed is how drastically the risk landscape changes for women at midlife. As menopause approaches, a woman’s cardiovascular risk doesn’t just gradually increase — it can surge, catching many by surprise.

The transition out of the estrogen-protected years transforms a woman’s internal physiology, setting off a cascade of changes that impact cholesterol metabolism, blood pressure, insulin sensitivity, and overall vascular health. More critically, while much of the focus remains on lifestyle and dietary factors, advancing technologies like genomic testing are revealing that a woman’s genetic makeup plays a substantial role in determining her unique cardiovascular risk — and how best to manage it.

Genomics, Hormones, and the Hidden Heart Risks of Menopause
In my 15 years of clinical practice using genomic testing, I’ve witnessed an extraordinary evolution. What was once dismissed as a novelty has become an indispensable tool in personalized medicine. Genomic insights now offer a deeper understanding of how each individual’s body operates beneath the surface — and nowhere is this more impactful than in managing heart health during and after menopause.

One of the most underrecognized aspects of menopause is how it equalizes heart disease risk between women and men. Estrogen, long known for its protective cardiovascular effects, declines dramatically in the menopausal years. This hormonal shift strips away a key line of defense, leaving women increasingly vulnerable to hypertension, high cholesterol, metabolic syndrome, and other components of cardiovascular disease.

What’s particularly sobering is that women who’ve maintained ideal cholesterol numbers, normal blood pressure, and healthy metabolic markers for decades may suddenly find themselves facing new cardiac risks. This isn’t merely a consequence of aging — it’s a biochemical shift, deeply influenced by genetics.

A fact that surprises many is that the majority of cholesterol circulating in our blood isn’t directly from the foods we eat; it’s produced by our own bodies. And how efficiently we produce, transport, and clear cholesterol is heavily dictated by our genetic code. Through genomic testing, we can pinpoint specific single nucleotide polymorphisms (SNPs) — tiny genetic variants — that influence cholesterol metabolism, particularly those impacting LDL receptors and other key pathways.

Armed with this information, clinicians can better anticipate where lifestyle modifications may be enough — and where additional interventions are likely necessary. Certain women, for instance, carry polymorphisms that make it difficult to regulate cholesterol through diet and exercise alone. For them, targeted therapies like red yeast rice, berberine, or even statins may be warranted much earlier than traditionally considered.

Importantly, sharing this genetic insight with patients often alleviates an unspoken burden. Too often, women are made to feel that poor cardiovascular health is solely the result of inadequate willpower or lifestyle choices. The narrative of “you just need to try harder” can be both damaging and inaccurate. Understanding that biology and genetics can place genuine limits on what lifestyle alone can achieve offers both clarity and compassion — and it allows for a more realistic, personalized, and effective care plan.

Conclusion:
As the dialogue around menopause broadens, it’s vital that cardiovascular health takes a front-row seat in these conversations. The hormonal shifts of midlife aren’t just about hot flashes and mood swings; they signify a major recalibration of a woman’s cardiovascular system. With the power of modern genomic testing and a more nuanced approach to care, we have the opportunity to intervene earlier, tailor treatments smarter, and support women with empathy rather than judgment.

Menopause should be seen not as a health crisis, but as a pivotal checkpoint — a time to reassess, recalibrate, and redefine what personalized, proactive heart health looks like for the modern woman.


Saturday, May 10, 2025

RECLAIMING MIDLIFE: Felicia Jackson’s Journey from Fashion to Wellness Advocacy





A New Era of Midlife Wellness Leadership
Across the country, a bold wave of advocates, coaches, and health-preneurs is reshaping the conversation around women’s midlife health. These passionate leaders are filling the gaps left by conventional care, offering resources, education, and empowering communities for women navigating the physical, emotional, and hormonal shifts of their forties and beyond.

Among them is Brooklyn-based wellness coach Felicia Jackson, whose inspiring journey from fashion executive to midlife health advocate reflects this growing movement. As an Integrative Nutritional Health Coach, Felicia helps women tackle some of midlife’s most disruptive symptoms — from weight gain and hot flashes to brain fog and chronic stress.

Driven by her own perimenopause experience, Felicia is on a mission to create safe, supportive spaces where women can reclaim control of their health. Through evidence-based nutrition and holistic lifestyle strategies, she helps clients rebalance hormones, boost energy, and rediscover confidence.

The Women’s Midlife Health Network proudly welcomes Felicia to our community of wellness leaders. Her compassionate voice and practical expertise are vital in breaking the silence around perimenopause and advocating for accessible, integrative care for all women in midlife.


A Personal Health Awakening
Felicia Jackson’s story is one many women will recognize — a narrative of personal reinvention sparked by the often-overlooked realities of midlife health. Living in Brooklyn, Jackson spent over two decades immersed in the fast-paced world of fashion, frequently traveling overseas while raising two young boys. The intensity of her career, combined with the demands of motherhood, left little time for herself. But as she approached her forties, Felicia began to sense profound changes in her health and wellbeing.

From Felicia's Blog on Hair Loss
Severe back pain, restless nights, and the unsettling onset of perimenopausal symptoms prompted her to seek answers. Disappointed by the limited solutions offered through conventional medical channels, Felicia turned inward — beginning a journey of personal research, self-advocacy, and ultimately, transformation. Through trial, error, and resilience, she embraced lifestyle adjustments, nutritional strategies, and stress-reduction practices that restored not only her physical health but her sense of confidence.

“That confidence that so many women lose in midlife — I was able to find it again,” she reflected. “I figured out who I was and where I wanted to go. And it all started with me helping myself feel better.”

From Fashion Executive to Health Coach
The pandemic years accelerated Jackson’s shift in priorities. After stepping back from full-time fashion work to support her family, she found herself, like many midlife professionals, edged out of an industry favoring younger talent. But what felt like a professional dead end became an opportunity to pivot.

Recognizing a deep need for better support systems for women in midlife, Felicia became certified as an Integrative Nutrition Health Coach in early 2024. Having personally navigated the emotional, physical, and hormonal upheavals of perimenopause, she was drawn to help others do the same.

“I knew when I started my certification program that I wanted to focus on midlife health and perimenopause,” she explained. “There’s just so much misinformation and a general lack of resources for women during this stage. My goal is to help them feel seen, supported, and empowered.”

Creating Tools for Women’s Midlife Health
One of Felicia’s most engaging contributions to the wellness space is her menopause symptom quiz — a user-friendly tool designed to categorize symptoms into four key areas: physical, mental, emotional, and sexual health. The quiz not only helps women identify their dominant symptoms but also provides personalized lifestyle recommendations, from nutrition tips to supplement options.

"Perimenopausal Skin"
“It’s a fun, easy way for women to start recognizing what’s going on in their bodies and why,” Felicia shared. “Each result page offers background on perimenopause, plus practical ways to improve those symptoms.”

Her commitment to accessible health solutions has driven her next major venture: a wellness app called Rise and Reset. Scheduled for release in mid-2025, the app features a six-week hormone reset program, focusing on small, actionable lifestyle changes. From establishing consistent morning routines to balancing cortisol through light exposure and mindful nutrition, the app emphasizes achievable steps rather than overwhelming overhauls.

“Coaching is tough, and not everyone can commit to one-on-one sessions,” Felicia acknowledged. “With this app, I’m hoping to reach more women where they are — on their phones — and give them the tools they need to start feeling better.”

Advocating for Women in Midlife and Beyond
Felicia Jackson is vocal about the cultural neglect of women after their childbearing years. She applauds healthcare professionals like Dr. Robert Bard, who prioritize women’s health at midlife and help demystify the often confusing landscape of perimenopause and menopause.

"Why Am I Always Hot?"
“There’s such a lack of education and awareness,” Felicia emphasized. “Our culture tends to forget about women past a certain age, but we have so much more to offer. I’m thrilled to see people supporting women at this stage and providing resources to help them thrive.”

Felicia is actively building networks with other health professionals and advocates, seeking partnerships that uplift and support women navigating midlife transitions. Whether through personal coaching, digital resources, or collaborative wellness projects, her mission remains clear: to help women rediscover confidence, reclaim their health, and embrace this chapter of life as a powerful and purposeful one.

Conclusion: A Story of Reinvention and Purpose
Felicia Jackson’s journey serves as both an inspiration and a roadmap for women seeking to redefine midlife on their own terms. What began as a personal health crisis evolved into a passionate mission to support other women through one of life’s most transformative seasons. By blending her professional experience, personal insight, and wellness education, she represents the very heart of the midlife health advocacy movement.

As more advocates, coaches, and health-preneurs rise to challenge outdated narratives and address the real needs of midlife women, stories like Felicia’s remind us that empowerment, health, and purpose aren’t confined to youth — they’re built, rediscovered, and embraced at every stage of life.

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FELICIA JACKSON spent nearly 20 years in the fashion industry as a designer and creative director for leading brands including Levi’s, Nautica, Aeropostale, American Eagle, and The Jones Group. With expertise spanning social media, fashion, tech, and lifestyle trends, she built a career as a brand builder with a keen cultural eye. Over time, her passion for health and wellness inspired a new chapter. Felicia became a certified Integrative Nutritional Health Coach through the Institute of Integrative Nutrition, focusing on women’s midlife health. Today, she supports women navigating perimenopause and midlife challenges, addressing symptoms like hot flashes, weight gain, brain fog, insomnia, and mood swings, as well as concerns like anxiety, joint pain, and thinning hair. Felicia partners with clients to naturally balance hormones and promote sustainable wellness through nutrition, movement, stress management, and mind-body practices. Combining her fashion background with personal health triumphs, Felicia offers a holistic, relatable approach to wellbeing, empowering women to reclaim their health, embrace midlife with confidence, and live with intention.


Seen, Heard, Empowered: What My Visit to Dr. Bard Taught Me About Midlife Health

Introduction

The Women’s Health Collaborative MIDLIFE Health Group is proud to present this powerful firsthand narrative by Sabine Gee, a dedicated Midlife Health & Menopause Coach and passionate advocate for women’s wellness. For years, Sabine has guided countless women over 45 through the complexities of perimenopause, seeking out forward-thinking tools and progressive care strategies that go beyond conventional medicine. Yet it was her long-awaited meeting with Dr. Robert Bard in New York City that would profoundly reshape her clinical perspective.

A pioneer in patient-centered diagnostics and the visionary behind the groundbreaking MenoScan, Dr. Bard offers a refreshingly transparent, hands-on approach to imaging and risk assessment for midlife women. Drawn by a shared commitment to addressing the overlooked and often dismissed symptoms of perimenopause, Sabine sought to experience firsthand how advanced imaging could reveal crucial insights often missed in traditional screenings.

This encounter not only deepened Sabine’s understanding of integrated midlife care but forged a meaningful alliance between two advocates committed to empowering women through proactive, personalized diagnostics. Together, their collaborative mission champions a future where women are seen, heard, and equipped with the knowledge to reclaim agency over their health journey.


"A Personal Journey Into Advanced Midlife Diagnostics
 As a Midlife Health & Menopause Coach, I’m always on the lookout for tools, research, and experts that help women over 45 reclaim their energy, confidence, and health. But sometimes, an experience leaves such a strong impression that it shifts your perspective entirely. That’s exactly what happened during my visit with Dr. Robert Bard in New York City.

Dr. Bard is not your typical radiologist. He is a pioneer in patient-centered diagnostics and the visionary behind the MenoScan—a groundbreaking set of advanced imaging protocols designed to identify hidden risk factors in midlife women. What sets him apart isn’t just the technology he uses, but how he uses it: with the patient, not behind the scenes.

Why I Went
As someone navigating midlife myself, I was curious about the real impact imaging could have on health outcomes—not just for me, but for my clients. I wanted to see what the MenoScan could reveal about my body and how it might complement traditional blood tests.

I was greeted warmly and shown around the office by Dr. Bard himself—a rare experience in today’s medical world. He listened attentively as I shared my health history and specific concerns, then tailored the session to fit my needs.

The Front-Row Experience
What followed was nothing short of remarkable. We began with thermal imaging of my hands and feet—checking for signs of inflammation and arthritic changes. He also performed thermal imaging of my neck and my eye—the latter to assess blood flow to the brain, which is a crucial indicator of brain health. From there, we transitioned to a scan of my neck and carotid artery. With each scan, Dr. Bard explained what we were seeing, in real time.

The most powerful moment? When he examined my thyroid and carotid artery while I sat beside him. The screen was visible to both of us. He explained the health of my thyroid, showed me the blood flow, and answered my questions with care. I felt part of the process. Seen. Heard. Empowered.

Why Imaging Matters
So many midlife women struggle with symptoms they don’t understand: fatigue, weight gain, anxiety, hot flashes. And too often, they’re told it’s all "just aging." But that’s not good enough.

Thyroid health, for example, often goes unchecked beyond a standard blood panel. Yet imaging can detect tissue changes or inflammation well before bloodwork reveals any issues. In fact, Dr. Bard explained that non-invasive tools like elastography and Doppler imaging can even help predict malignancy or rule it out, guiding early intervention.

And when it comes to cardiovascular health, many women are shocked to learn that heart disease is the #1 cause of death post-menopause. While I had recommended calcium scans in the past, I was amazed to learn that Dr. Bard's ultrasound-based scan of the carotid artery can detect early vascular changes even before calcium scans show plaque. This is crucial information for women deciding whether HRT is right for them.

It’s important to note that these are just a few of the many tools included in the comprehensive MenoScan protocol. To explore the full range of what the MenoScan offers, visit: www.menoscan.org


A Diagnostic Revolution
Dr. Bard is revolutionizing how we approach diagnostics. In most U.S. clinics, a technician does the scan, a radiologist reads it later, and the results are then relayed to the patient via yet another doctor—a sharp contrast to what I’m used to in Europe, where each doctor typically performs and interprets their own imaging.

Dr. Bard defies this fragmented model. He holds the probe himself, interprets the scans in real time, and makes the patient an informed partner in the process.

He’s also not afraid of potential litigation or protocols that discourage real-time patient dialogue. Instead, he believes in transparency, empowerment, and human connection—qualities that are sadly rare in modern medicine.

As Dr. Bard says:
"We don't just look for disease. We look for patterns, for early changes, for what might become disease. That's where prevention begins.”


The Future of Midlife Health
The MenoScan is more than a test—it’s a foundation for informed decision-making. Combined with bloodwork and a skilled practitioner, it gives women a full picture of what’s really happening inside their bodies. It highlights the multi-factorial nature of menopause: how hormones, cardiovascular function, thyroid health, inflammation, and even mental well-being are interconnected.

Too often, women are prescribed antidepressants during perimenopause when the real issue is hormonal fluctuation. Too often, they’re told “nothing is wrong,” or that symptoms are "just part of aging."

But as I always say: "The ones with symptoms are the lucky ones.”

Because at least their bodies are speaking up, prompting women to look for solutions, so they can take charge of their health and a healthy, active & joyful next chapter. Let’s stop brushing off women’s symptoms. Let’s start offering them real answers, powerful tools, and a seat at the table when it comes to their own health. Thanks to Dr. Bard, I left not only reassured but equipped—with knowledge, images, and insight I could use to take the next step in my health journey. Every woman deserves this.



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Epilogue: Building Bridges for Women’s Health Advancement
By: Dr. Barbara Bartlik & Marilyn Abrahamson

In today’s complex healthcare landscape, meaningful change rarely happens in isolation. True progress is born from collaboration—when medical pioneers, health coaches, patient advocates, and wellness professionals join forces in pursuit of a common goal. This narrative reflects the growing importance of building bridges between clinical experts like Dr. Robert Bard and passionate non-medical professionals like Sabine Gee, whose firsthand insights into the lived experiences of midlife women enrich the dialogue around care.

Click to see the full results of this event

Forging these alliances is essential in the ongoing crusade for better education, advocacy, and diagnostic innovation. Women navigating perimenopause and beyond deserve a healthcare model where expertise is shared, silos are dismantled, and new ideas flourish. By networking across disciplines, we foster environments where groundbreaking technologies like the MenoScan reach those who need them most—and where women’s health concerns are met with real solutions, not dismissive platitudes.

The Women’s Health Collaborative MIDLIFE Health Group stands as a testament to this mission. Together, we amplify each other’s work, validate women’s experiences, and accelerate the movement toward comprehensive, patient-centered care. The future of midlife health belongs to those who are bold enough to build it together.




Common History of Patients Who Benefit from Imaging

Written By: Dr. Robert L. Bard | Edited by: Graciella Davi

Introduction
Advancements in diagnostic imaging have transformed the way clinicians approach complex, multisystem diseases, especially those with subtle or overlapping symptoms. This review presents a case study highlighting the integrative role of advanced imaging modalities in detecting and managing thyroid abnormalities and associated cardiovascular conditions in a perimenopausal patient. A female in her late 40’s with borderline laboratory results, unexplained weight gain, and elevated blood pressure serves as the clinical focus for this comprehensive diagnostic workup.

The initial thyroid sonogram, a cornerstone in endocrine evaluation, identified abnormalities requiring further functional and structural imaging. Technologies such as Doppler imaging, 3D volume histogram analysis, elastography, and spectroscopy were employed to define tissue characteristics, vascular flow, and fibrotic changes. Concurrently, thermology and microvascular mapping revealed evidence of cardiovascular involvement, prompting a broader physiologic assessment.

The article further discusses the emerging connection between endocrine and cardiovascular dysfunctions in perimenopausal women, exploring the diagnostic potential of non-invasive thermal imaging and AI-enhanced technologies. It also emphasizes the value of integrative, real-time imaging techniques in differentiating inflammation from malignancy and guiding therapeutic decisions. These evolving modalities represent the future of personalized, precision medicine in diagnosing and managing chronic inflammatory, vascular, and oncologic diseases.

Routine thyroid sonograms begin with bilateral transverse and longitudinal views. If abnormalities are detected, additional modalities such as functional Doppler imaging, 3D volume histogram, M-mode tissue signature scan, 405nm spectroscopy, microvascular mapping, thermology, and elastography may be employed.

Fig. 1 - In the transverse scan of the left thyroid gland, the initial contact echoes originate from the dermis (moderately echogenic), followed by subcutaneous tissue (echo poor), and linear fascial tissue overlying the deeper muscle layer. The trachea (with two cartilage rings), thyroid gland, and cross-section of the common carotid artery are labeled. The upper lobe demonstrates an echo-poor medial pattern, while the lateral segment retains a normal, moderately echogenic texture.



Due to multiple abnormalities, advanced diagnostic imaging was utilized:

Functional Doppler imaging revealed decreased blood flow in both lobes.
3D volume histogram mapped the extent of fibrotic regions.
M-mode tissue signature scan quantified poor sound penetration due to scarring.
405nm spectroscopy ruled out bacterial disease.
Microvascular mapping provided a treatment guide.
Thermology with strain elastography outlined the borders of poorly functioning tissue.
Shear wave elastography (SWE) quantified the degree of fibrosis, aiding therapeutic planning.

















CARDIOVASCULAR SYSTEM ASSESSMENT
As evidence of cardiovascular involvement emerged, further evaluation with thermologic modalities was pursued. Thermology is a non-invasive physiologic and biologic assessment of the cardiovascular system, employing autonomic stress to provoke functional changes — much like a stress test. Hemodynamic challenges are visualized, guiding the physician to identify the most vulnerable anatomic areas.

The value of this technology in cardiovascular screening was noted serendipitously during breast cancer investigations, where abnormal carotid artery circulation in the neck was detected. Similarly, while scanning facial skin for psoriasis and rosacea, notable differences in post-stress physiologic blood flow images were observed. Concussion patients also demonstrated functional distortions in orbital circulation symmetry, correlating with increased intracranial pressure from slowly developing post-traumatic subdural hematomas.


Detecting Perimenopausal Cardiovascular Disease (CVD)
While reviewing the medical history from an anomalous breast examination, a connection to underlying cardiac dysfunction was uncovered.  Elastography documents fibrosis (Fig 3,5) and even identified post-viral myocarditis and post-vaccine cardiac reactions more recently.  

While chronic heart failure in women is reliably diagnosed through echocardiography and EKG, the subtle, silent nature of early arterial stenosis and cardiomyopathy presents a clinical dilemma — one that may be addressed with AI-enhanced thermal screening technologies.

The Future
The development of a non-invasive, cost-effective, and quantitative tool for CVD screening holds promise. Conditions such as endometriosis, inflammatory diseases (like psoriasis), and arteritis (Fig. 2, 4) may benefit from ultrasound elastography’s capacity to detect vascular inflammation.

Therapeutic Advances
Emerging strategies now combine thermal imaging, epigenetic analysis, and microvascular/photoacoustic ultrasound — a diagnostic platform capable of differentiating malignancies from inflammation, while quantitatively assessing metastatic potential in real time. This capability allows for on-the-spot evaluation of treatment efficacy. This innovation is particularly impactful in melanoma care, where aggressive tumors are highly vascular and thermally active. Intriguingly, successfully treated tumors may enlarge as they necrose — a feature now trackable through these technologies. Such advancements are expected to expand into managing diseases like psoriasis, endometriosis, thyroiditis, lupus, and Lyme disease, alongside non-surgical bioenergy therapies.

Conclusion
This case study underscores the vital role of advanced, multimodal imaging in the early detection and management of complex, multisystem conditions, particularly in perimenopausal women who often present with subtle or atypical clinical findings. Through the integration of conventional ultrasound with advanced technologies such as Doppler imaging, 3D volume histograms, M-mode tissue analysis, spectroscopy, elastography, and thermology, a comprehensive diagnostic picture was established. These imaging modalities not only identified structural thyroid abnormalities but also revealed functional vascular impairments and early cardiovascular involvement.

The findings highlight the evolving connection between endocrine dysfunction, inflammatory disease, and cardiovascular risk in midlife women — a demographic often underrepresented in cardiovascular research. Additionally, the potential of AI-enhanced thermal imaging and photoacoustic ultrasound to distinguish inflammation from malignancy and to quantify metastatic activity in real time represents a significant advancement in personalized medicine.

As diagnostic imaging continues to evolve, integrating physiologic, metabolic, and structural assessments will enable earlier detection, more precise characterization of disease processes, and the ability to monitor treatment efficacy non-invasively. This multidisciplinary, technology-driven approach promises to improve outcomes not only in oncology but also in chronic inflammatory and vascular diseases that remain challenging to detect in their earliest stages.

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ABOUT THE AUTHOR-

ROBERT L. BARD, MD, PC, DABR, FASLMS - Advanced Imaging & Diagnostic Specialist

Having paved the way for the study of various cancers both clinically and academically, Dr. Robert Bard co-founded the 9/11 CancerScan program to bring additional diagnostic support to all first responders from Ground Zero. His main practice in midtown, NYC (Bard Diagnostic Imaging- www.CancerScan.com) uses the latest in digital Imaging technology has been also used to help guide biopsies and in many cases, even replicate much of the same reports of a clinical invasive biopsy. Imaging solutions such as high-powered Sonograms, Spectral Doppler, sonofluoroscopy, 3D/4D Image Reconstruction and the Spectral Doppler are safe, noninvasive, and does not use ionizing radiation. It is used as a complement to find anomalies and help diagnose the causes of pain, swelling and infection in the body’s internal organs while allowing the diagnostician the ability to zoom and ‘travel’ deep into the body for maximum exploration.

Monday, May 5, 2025

Alzheimer’s Disease: One Woman’s Journey to Helping Women Redefine Their Midlife

Written by: Roberta Morris, Wellness Coach, CHHC, AADP, CC                                                                                                              

Imagine a world where someone you love is right beside you—but no longer truly present. Now, picture being just 8 years old, and that person is your grandmother… someone you adored. Suddenly, you can no longer talk to her, share those special moments, or childhood secrets. The hugs and kisses you once cherished are gone.

My grandmother lived with us. We shared many cherished moments before I turned eight. She usually cooked our meals, but our Friday night dinners were special. As she prepared the food for that evening, I would stand on a stool beside her, watching closely as she worked. For dessert, my grandmother would always bake two apple pies: one large enough for the entire family and the other, a smaller version that she claimed was "prepared" by me. I can still remember looking up at her, smiling with pride and feeling the warmth of our bond. 

Then, one day, everything changed. My grandmother was still with us, but her memory began to fade. Before long, she no longer recognized me. Just like that, all those cherished moments ended abruptly.

My grandmother was diagnosed with cerebral arteriosclerosis, commonly referred to as hardening of the arteries in the brain. Limited information was available about this condition. Subsequent research identified it as a form of Alzheimer’s disease. At that time, the medical understanding of the pathology and progression of Alzheimer's was still in its early developmental stages.

Staying informed on emerging research and advancements in the field over the years ultimately led me to become an advocate for the Alzheimer’s Association. One critical insight shaped the direction of my work: biological differences place women at a significantly higher risk for Alzheimer’s than men. Already a wellness expert, this knowledge strengthened my commitment to supporting women, particularly those transitioning through menopause.

Each year, over a million women enter menopause, yet the transition itself remains widely misunderstood. A persistent lack of education and support—compounded by the stigma surrounding aging—leaves many women believing their productive years are behind them. When open conversations about menopause are avoided, even with friends, family, or healthcare providers, managing symptoms becomes especially challenging.

The scope of my practice is to help women recognize that while their reproductive years may have ended, their productive, vibrant years are far from over. With the right information, encouragement, and lifestyle habits, they can feel empowered, healthy, and confident. Often, this journey begins with a clear explanation of what menopause is, including its stages and common experiences. From there, we shift the focus to the role a healthy lifestyle plays in thriving through this new phase of life.



MENOPAUSE OCCURS IN THREE DISTINCT PHASES

Perimenopause: This transitional stage begins when menstrual cycles become irregular and other menopause-related symptoms, such as hot flashes, night sweats, and mood swings, first emerge. This phase continues up to and includes the point of menopause, which is officially marked by 12 consecutive months without a menstrual period. 

Menopause: Signifying the end of menstruation and natural fertility, menopause is a normal biological process triggered by the gradual decline in ovarian function and a significant drop in hormone levels, especially estrogen.

Post-Menopause: This phase begins after menopause and lasts for the rest of a woman’s life. Although most menopausal symptoms tend to subside during post-menopause, some mild symptoms may persist for several years.


Menopause, while a natural biological transition in a woman's life, marks a critical period when the body becomes more susceptible to a range of health challenges. Although many chronic conditions—such as cardiovascular disease, breast cancer, osteoporosis, diabetes, and genitourinary syndrome of menopause (GSM)—may begin developing years before symptoms appear, menopause can hasten their progression.

During her interview on TED Talk Radio Hour hosted by Manoush Zomorodi, Lisa Mosconi, PhD, Neuroscientist, emphasized that menopause is not merely the end of menstruation, but also encompasses profound changes in the brain — affecting its structure, function, and biochemistry. “The health of the ovaries is linked to the health of the brain and the other way around. At the same time, hormones like estrogen are not only involved in reproduction but also in brain function. And estrogen in particular, or estradiol, is really key for energy production in the brain. At the cellular level, estrogen literally pushes neurons to burn glucose to make energy. If your estrogen is high, your brain energy is high. When your estrogen declines, though, your neurons start slowing down and age faster. For women, brain energy is usually fine before menopause, but then it gradually declines during the transition. And this was found independent of age. It didn't matter if the women were 40, 50, or 60. What mattered most was that they were in menopause.”

The gut-brain connection is a sophisticated, two-way communication pathway linking the brain and digestive system—each deeply affecting the other. This vital relationship, known as the gut-brain axis, becomes especially significant for women navigating menopause. By nourishing the gut with supportive, nutrient-rich foods, she can enhance brain function and cognitive wellbeing.

Making healthy lifestyle choices during the menopause transition may help control a woman’s symptoms and slow the progression of disease.


Quality Sleep:
Hormonal fluctuations during menopause may significantly disrupt the sleep cycle, often leading to insomnia. Mood swings and heightened anxiety may also keep women awake. Coupled with the discomfort of night sweats, sleep may feel elusive during this life stage.

Establishing a consistent sleep routine becomes essential for managing these challenges. Simple adjustments—such as creating a regular sleep schedule, reducing screen time, and avoiding strenuous exercise before bedtime—may make falling and staying asleep easier.

Balanced Nutrition:  The Mediterranean lifestyle encompasses more than just diet. Daily physical activity and sharing meals with others are vital components. Together, they may profoundly influence mood and mental health, fostering a deep appreciation for the enjoyment of consuming healthy and delicious foods.

Incorporating dairy products, healthy fats, whole grains, fruits, vegetables, foods rich in phytoestrogens, antioxidants, and high-quality protein into your diet may help alleviate some menopause symptoms. As your body undergoes significant changes during menopause, incorporating adequate essential nutrients like protein and fiber is especially important. A Mediterranean diet—rich fresh produce, nuts, fish, and olive oil—may also play a crucial role in reducing the risk of serious health issues.

Physical Activity:  Menopause affects each woman differently. Regular physical activity may be a powerful ally during menopause, helping to reduce stress and ease common symptoms. Embracing a more active lifestyle may also contribute to long-term health by lowering the risk of age-related conditions. Set realistic goals. Consider walking, gardening, or strength training—whatever keeps you motivated!  


Effective Stress Management: 
Hormonal shifts during perimenopause and menopause may intensify the stress response, often leading to anxiety, low mood, and feelings of overwhelm. Chronic stress—fueled by a poor diet, conflict, or constant worry—raises cortisol levels, which can trigger fatigue, brain fog, insomnia, heightened menopause symptoms, and increase the risk of heart disease, stroke, and diabetes. Managing stress is essential, and simple practices like meditation, breathing exercises, walking, journaling, or engaging in hobbies such as reading or gardening can make a powerful difference in restoring balance and well-being.  

Incorporating healthy lifestyle habits—such as quality sleep, balanced nutrition, regular physical activity, and effective stress management—can significantly impact the menopause transition. These choices may help alleviate symptoms and slow the progression of age-related diseases, promoting long-term health and well-being.


Ted Radio Hour, NPR: “Menopause brain’ is a real thing. Here's what to do about it.”  NPR: TED Radio Hour. Manoush Zomorodi, Host, Nov 11, 2022. https://www.npr.org/transcripts/973805003

Mosconi, L., Rahman, A., Diaz, I., et al. (2021). “Perimenopause and emergence of an Alzheimer’s bioenergetic phenotype in brain and periphery.” https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0185926

Sayón-Orea, C., Santiago, S, et al.(2015). “Adherence to Mediterranean dietary pattern and menopausal symptoms in relation to overweight/obesity in Spanish perimenopausal and postmenopausal women.“ https://journals.lww.com/menopausejournal/abstract/2015/07000/adherence_to_mediterranean_dietary_pattern_and.13.aspx

Safabakhsh, M., Siassi, F., et al. (2020). “ Higher intakes of fruits and vegetables are related to fewer menopausal symptoms: a cross-sectional study.” https://journals.lww.com/menopausejournal/abstract/2020/05000/higher_intakes_of_fruits_and_vegetables_are.15.aspx

Erdelyi, A., Tuu, L., et al. (2023). “The Importance of Nutrition in Menopause and Perimenopause—A Review.” https://pmc.ncbi.nlm.nih.gov/articles/PMC10780928/

Peters, B. A., Santoro, N., et al (2022). “Spotlight on the Gut Microbiome in Menopause: Current Insights.” https://pmc.ncbi.nlm.nih.gov/articles/PMC9379122/

“Mayo Clinic Minute: Managing sleep during menopause.” Mayo Clinic News Network. Sonya Goins, Author. Oct 18, 2023. https://newsnetwork.mayoclinic.org/discussion/mayo-clinic-minute-managing-sleep-during-menopause/

Dąbrowska-Galas M., Ptaszkowski K., et al. (2019). “High Physical Activity Level May Reduce Menopausal Symptoms.” https://pmc.ncbi.nlm.nih.gov/articles/PMC6722698/

Taylor-Swanson, L., Wong, A.E., et al. (2018). “The Dynamics of Stress and Fatigue across Menopause: Attractors, Coupling and Resilience.” https://pmc.ncbi.nlm.nih.gov/articles/PMC5866170/

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ABOUT THE AUTHOR

ROBERTA MORRIS is a wellness expert, neuro-nutrition specialist, and founder of Roberta M…Women Redefining Midlife, a platform devoted to helping women navigate menopause and beyond with confidence and clarity. After entering this life stage unprepared, Roberta made it her mission to break the stigma by providing education, holistic counseling, and workplace consultation. Her signature program, It’s My Turn, empowers women to manage the physical, emotional, and lifestyle changes of midlife—reclaiming their vitality. As a passionate advocate for menopause inclusivity in the workplace, she helps organizations create supportive, health-forward environments for women. Roberta’s lifelong commitment to wellness is grounded in the pillars of nutrition, sleep, movement, and stress management. After witnessing her grandmother’s decline from Alzheimer’s, Roberta became an ambassador advocate for the Alzheimer’s Association. One critical insight: biological differences place women at a significantly higher risk for Alzheimer’s than men—this realization deepened her commitment to supporting women through midlife transitions.



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INSPIRATION FROM A FELLOW MIDLIFE COACH

"Thank you, Roberta, for your powerful and deeply personal article highlighting the connection between menopause and brain health. Your story about your grandmother touched me deeply — and your explanation of how the decline in estrogen impacts our brain is one every woman deserves to hear. So often, I still hear women say, “Oh, I don’t really have symptoms,” or “I’m through it.” And silently, I panic — not because I want to scare them, but because I want them to understand: it’s not just about managing the short-term symptoms. It’s about protecting our long-term health — our hearts, bones, metabolism, and yes, our brains.

Your work is so beautifully aligned with mine. Helping women understand what’s going on and guiding them to make lifestyle changes now is how we set the stage for a vibrant, healthy, and clear-minded 30+ years ahead.  This is why we act now. Thank you for your ongoing advocacy and your compassionate voice in redefining midlife for women everywhere." 

By Sabine Gee, Midlife Health & Menopause Expert 




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Saturday, May 3, 2025

BEYOND HORMONES (part 2): A Functional Blueprint for Cardiometabolic Health in Menopause

By Hwaida Hannoush, MD FASE 


ADVANCED CARDIOMETABOLIC ASSESSMENT IN MENOPAUSE

A comprehensive functional evaluation includes:

1. Metabolic Markers
Fasting insulin, HOMA-IR
Triglyceride-glucose index (TyG)

2. Lipid and Particle Analysis
     ApoB (superior to LDL-C for predicting             atherogenic particle burden)
     Lipoprotein(a) [Lp(a)]: Elevated post-menopause and minimally responsive to statins
    • Oxidized LDL (oxLDL)

3. Inflammatory and Immune Biomarkers
     hs-CRP, fibrinogen , MPO, Lp-PLA2
    • autoimmune markers (ANA, thyroid antibodies)
     IL-6 and TNF-α (in select high-risk cases)

4. Endocrine and Hormonal Dynamics

     Estradiol, progesterone, testosterone, and cortisol
     Full Thyroid panel (TSH, free T3/T4, reverse T3, thyroid antibodies)


5. Vascular Imaging and Function                                                                                                      

     CAC score: Critical in identifying subclinical plaque in asymptomatic women
     Coronary CT Angiography with Flow Reserve (FFR-CT):Coronary CT angiography with fractional flow reserve (FFR-CT) is a non-invasive imaging modality that combines high-resolution anatomical visualization of the coronary arteries with computational assessment of blood flow dynamics. It not only evaluates flow-limiting lesions but also characterizes plaque morphology—distinguishing between soft, mixed, and calcified plaque. Identifying high-risk, non-calcified (soft) plaque is critical, as it is more vulnerable to rupture and serves as a powerful predictor of future cardiovascular events.
     CIMT, EndoPAT: Evaluate endothelial and arterial health


6. Microbiome and Detoxification Assessment

Stool Analysis assesses microbiota composition, inflammation, and β-glucuronidase activity, a key indicator of estrobolome function. Elevated enzyme levels suggest increased estrogen reactivation, contributing to estrogen dominance. It also identifies dysbiosis and guides microbiome-targeted therapies.

Complete Hormone Test evaluates estrogen metabolism (2-OH, 4-OH, 16-OH pathways), adrenal function, and cortisol rhythms. Patterns of impaired detoxification may point to gut-liver axis dysfunction, especially when interpreted alongside stool analysis results.

Organic Acid and Stool Metabolomics detect microbial imbalances, nutrient deficiencies, and cardiometabolic risk markers like TMAO and butyrate. Low butyrate indicates reduced anti-inflammatory capacity and impaired gut barrier function.


7. Oral Health

     Periodontal disease assessment by biologic or holistic dentists. 



8. Thyroid Health

Thyroid function optimization to reduce lipid and blood pressure dysregulation


9. Micronutrients: Vitamin D, B-complex, omega-3s, magnesium

10. Autoimmunity & Detoxification: ANA, GGT, homocysteine, albumin-creatinine ratio

11. Genetics: ApoE, MTHFR polymorphisms

12. The Role of Digital Biomarkers: CGM, HRV, and Beyond

In modern integrative cardiology, wearable and digital diagnostics offer real-time, actionable insights. Continuous glucose monitors (CGMs) help identify glycemic variability, postprandial hyperinsulinemia, and reactive hypoglycemia—often missed by fasting glucose or HbA1c alone. In perimenopausal women, CGM data frequently reveals dysregulated glucose metabolism months before overt metabolic syndrome emerges.

Similarly, heart rate variability (HRV) monitoring provides a window into autonomic tone and recovery capacity. Lower HRV correlates with heightened sympathetic activity, impaired vagal tone, and increased cardiovascular event risk [7]. HRV, combined with wearable sleep metrics and fitness trackers, enables dynamic assessment of recovery, stress response, and circadian alignment—key variables during menopausal transition.

Digital data bridges the gap between clinical encounters and daily lived physiology. When integrated with labs, imaging, and patient-reported outcomes, tools like CGM and HRV enable continuous, individualized risk profiling.


KEY THERAPEUTIC PILLARS: FROM MOLECULES TO MOVEMENT

1. Lifestyle and Risk Modification: The Evidence is Clear- A recent study [23] showed that women with high lifestyle adherence (non-smoking, optimal sleep, regular exercise, healthy diet, less sitting) had:

     23% lower odds of CVD overall

     52% lower odds of CVD if they had premature menopause

    a. Restorative sleep (7–8 hours) is essential for regulating blood pressure, cortisol levels, and cardiometabolic function.

    b. Evidence-based stress management strategies like mindfulness, yoga, breathing exercises, and biofeedback improve heart rate variability and reduce cardiovascular events.

    c. Exercise Prescription

    • Resistance Training: 2–3x/week to counteract sarcopenia and improve insulin sensitivity [12]
    • Zone 2 Cardio: 150 minutes/week for mitochondrial and endothelial health
VO₂max Tracking: Predictive of cardiovascular and overall mortality

    d. Precision Nutrition

    • Mediterranean diet with added protein (~1 g/lb ideal body weight)
     Anti-inflammatory foods (omega-3s, polyphenols, fermented fibers)
     Time-restricted eating and CGM-guided meal timing


3. TARGETED SUPPLEMENTATION

    • CoQ10: Mitochondrial and statin support
     Omega-3s: Reduce triglycerides and inflammation [16]
     Magnesium: Supports blood pressure, insulin sensitivity, and HRV
     Vitamin K2/D3: Prevent arterial calcification while supporting bone health
     Berberine, curcumin, resveratrol: Modulate insulin, lipids, and inflammation
     Glycocalyx and nitric oxide support


4. Biodentical Hormone Therapy (BHRT)

Safest when started within 5–10 years of menopause
Bioidentical testosterone, estradiol + micronized progesterone preferred
Lowers Lp(a), improves endothelial function, and reduces central adiposity in select candidates [20]


5. GUT HEALTH OPTIMIZATION

Prebiotic fibers and polyphenols
Butyrate-producing probiotics
Phase II liver detox support (glutathione, methylation cofactors)


THE FUNCTIONAL CARDIOLOGY MANDATE 

Cardiovascular disease in women does not begin with symptoms. Up to 90% of asymptomatic individuals show plaque on coronary CT angiography [6]. Early detection—via imaging, digital tracking, and advanced biomarkers—transforms prevention from reactive to proactive.

Digital tools like CGM and HRV quantify real-time physiological stress and recovery. Combined with biometrics (muscle mass, VO₂max, waist-to-hip ratio) and laboratory metrics, they enable longitudinal, precision-based interventions that shift the trajectory of cardiovascular aging.


Conclusion: Precision Prevention as the New Standard

Menopause is not a disease, but a signal to recalibrate care. Functional cardiology reframes this transition as an opportunity for metabolic reprogramming—one rooted in data, physiology, and personalization.

This blueprint—merging functional diagnostics, wearables, imaging, and targeted therapy—provides a comprehensive framework to prevent cardiovascular decline and foster resilience. When implemented early and systematically, it empowers women to reclaim control over their cardiometabolic destiny.

The heart is not merely an organ; it reflects whole-body health. And for women in midlife, it deserves a whole-body, systems-based approach to care.



ABOUT THE AUTHOR

Dr. Hwaida Hannoush is an Internal Medicine provider in Lanham, Maryland. Dr. Hannoush is highly rated in 1 condition. Her top areas of expertise are Alstrom Syndrome, Sickle Cell Disease, Congenital Hemolytic Anemia, and Hemoglobinopathy. Her clinical research consists of co-authoring 11 peer reviewed articles. MediFind looks at clinical research from the past 15 years. She specializes in Women with strong family history of heart disease and those who are high-performers who want clarity, energy, and long-term resilience. (for more information, visit her website @ https://empowered-women-hearts.mn.co/


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